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Found 2 hits Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM456542'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM456542
PNG
(US10723742, Example 271 | US11510915, Example 271)
Show SMILES Cc1c(F)c(cc2nnn(CC3(O)CCC3)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1CC[C@H](N)C1
Show InChI InChI=1S/C30H28F2N6O2/c1-17-27(32)24(13-26-28(17)38(36-35-26)16-30(40)8-2-9-30)22-6-5-19(29(39)37-10-7-21(34)15-37)11-23(22)18-3-4-20(14-33)25(31)12-18/h3-6,11-13,21,40H,2,7-10,15-16,34H2,1H3/t21-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.230n/an/an/an/an/an/a


TBA

Assay Description
The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC6513
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM456542
PNG
(US10723742, Example 271 | US11510915, Example 271)
Show SMILES Cc1c(F)c(cc2nnn(CC3(O)CCC3)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1CC[C@H](N)C1
Show InChI InChI=1S/C30H28F2N6O2/c1-17-27(32)24(13-26-28(17)38(36-35-26)16-30(40)8-2-9-30)22-6-5-19(29(39)37-10-7-21(34)15-37)11-23(22)18-3-4-20(14-33)25(31)12-18/h3-6,11-13,21,40H,2,7-10,15-16,34H2,1H3/t21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.230n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...


US Patent US10723742 (2020)


BindingDB Entry DOI: 10.7270/Q2TF01DB
More data for this
Ligand-Target Pair