BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'M-phase inducer phosphatase 1' and Ligand = 'BDBM50208827'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
M-phase inducer phosphatase 1 (Homo sapiens (Human))	BDBM50208827 (2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione \|...) Show SMILES OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O \|c:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Max-Planck-Institute of Molecular Physiology Curated by ChEMBL					Assay Description Inhibition of human Cdc25A				Bioorg Med Chem 19: 2145-55 (2011) Article DOI: 10.1016/j.bmc.2011.02.047 BindingDB Entry DOI: 10.7270/Q2BR8SHK
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 1 (Homo sapiens (Human))	BDBM50208827 (2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione \|...) Show SMILES OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O \|c:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza University of Rome Curated by ChEMBL					Assay Description Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes.				Eur J Med Chem 134: 316-333 (2017) Article DOI: 10.1016/j.ejmech.2017.04.012 BindingDB Entry DOI: 10.7270/Q2WD4311
Sapienza University of Rome Curated by ChEMBL					More data for this Ligand-Target Pair
M-phase inducer phosphatase 1 (Homo sapiens (Human))	BDBM50208827 (2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione \|...) Show SMILES OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O \|c:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University Curated by ChEMBL					Assay Description Inhibition of recombinant Cdc25A (unknown origin) using OMFP as substrate measured every 30 sec for 10 mins by fluorometric assay				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111719 BindingDB Entry DOI: 10.7270/Q2D221X9
Montana State University Curated by ChEMBL					More data for this Ligand-Target Pair
M-phase inducer phosphatase 1 (Homo sapiens (Human))	BDBM50208827 (2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione \|...) Show SMILES OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O \|c:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sejong University Curated by ChEMBL					Assay Description Inhibition of Cdc25A (336-523) (unknown origin) expressed in Escherichia coli				J Med Chem 51: 5533-41 (2008) Article DOI: 10.1021/jm701157g BindingDB Entry DOI: 10.7270/Q20V8CMW
Sejong University Curated by ChEMBL					More data for this Ligand-Target Pair
M-phase inducer phosphatase 1 (Homo sapiens (Human))	BDBM50208827 (2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione \|...) Show SMILES OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O \|c:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sejong University Curated by ChEMBL					Assay Description Inhibition of N-terminal 6xHis-tagged human Cdc25A (336-523) catalytic domain expressed in Escherichia coli after 20 mins by fluorescent plate reader...				Bioorg Med Chem Lett 19: 4330-4 (2009) Article DOI: 10.1016/j.bmcl.2009.05.084 BindingDB Entry DOI: 10.7270/Q2NZ87P2
Sejong University Curated by ChEMBL					More data for this Ligand-Target Pair