Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit [D816V]' and Ligand = 'BDBM369250'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM369250 (N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(1,3- dimeth...) Show SMILES C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C26H30ClN7OS/c1-16(18-7-6-8-19(27)11-18)30-25(35)34-10-9-33(14-26(34,3)4)24-23-21(28-15-29-24)12-22(36-23)20-13-32(5)31-17(20)2/h6-8,11-13,15-16H,9-10,14H2,1-5H3,(H,30,35)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universitàadi Roma					Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...				J Med Chem 51: 1560-76 (2008) BindingDB Entry DOI: 10.7270/Q2HX1FZW
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