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Found 1 hit Enz. Inhib. hit(s) with Target = 'Matrix metalloproteinase-14' and Ligand = 'BDBM50450414'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Matrix metalloproteinase-14


(Homo sapiens (Human))		BDBM50450414
PNG
(CHEMBL4162305)
Show SMILES CNC(=O)[C@@H](NC(=O)c1ccc(o1)-c1ccc(CSc2nccc(=O)[nH]2)c(F)c1)C(C)C |r|
Show InChI InChI=1S/C22H23FN4O4S/c1-12(2)19(21(30)24-3)27-20(29)17-7-6-16(31-17)13-4-5-14(15(23)10-13)11-32-22-25-9-8-18(28)26-22/h4-10,12,19H,11H2,1-3H3,(H,24,30)(H,27,29)(H,25,26,28)/t19-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Graz University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP14 expressed in Escherichia coli using fTHP-15 as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem 26: 4984-4995 (2018)


Article DOI: 10.1016/j.bmc.2018.08.020
BindingDB Entry DOI: 10.7270/Q25141SR
More data for this
Ligand-Target Pair