Found 6 hits Enz. Inhib. hit(s) with Target = 'Melanocortin receptor 4' and Ligand = 'BDBM135777' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM135777
(US10179804, Example 162 | US10632171, Peptide No. ...)Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Palatin Technologies, Inc.
US Patent
| Assay Description A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o... |
US Patent US8846601 (2014)
BindingDB Entry DOI: 10.7270/Q2SF2TWK |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM135777
(US10179804, Example 162 | US10632171, Peptide No. ...)Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 5 | -49.3 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Palatin Technologies, Inc.
US Patent
| Assay Description A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o... |
US Patent US9458201 (2016)
BindingDB Entry DOI: 10.7270/Q2HT2N79 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM135777
(US10179804, Example 162 | US10632171, Peptide No. ...)Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Palatin Technologies, Inc.
US Patent
| Assay Description A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o... |
US Patent US10632171 (2020)
BindingDB Entry DOI: 10.7270/Q2BG2S18 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM135777
(US10179804, Example 162 | US10632171, Peptide No. ...)Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Palatin Technologies, Inc.
US Patent
| Assay Description Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ... |
US Patent US10179804 (2019)
BindingDB Entry DOI: 10.7270/Q24T6MFP |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM135777
(US10179804, Example 162 | US10632171, Peptide No. ...)Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Palatin Technologies, Inc.
US Patent
| Assay Description A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o... |
US Patent US10632171 (2020)
BindingDB Entry DOI: 10.7270/Q2BG2S18 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM135777
(US10179804, Example 162 | US10632171, Peptide No. ...)Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | n/a | n/a | 0.850 | n/a | n/a | 7.5 | 37 |
Palatin Technologies, Inc.
US Patent
| Assay Description Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ... |
US Patent US9458201 (2016)
BindingDB Entry DOI: 10.7270/Q2HT2N79 |
More data for this Ligand-Target Pair | |