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Found 1 hit Enz. Inhib. hit(s) with Target = 'Menin' and Ligand = 'BDBM50496345'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Menin


(Homo sapiens (Human))		BDBM50496345
PNG
(CHEMBL3126200)
Show SMILES NS(=O)(=O)c1ccc(OCCCN2CCC(CC2)C(O)(c2cccc(F)c2)c2ccccn2)cc1
Show InChI InChI=1S/C26H30FN3O4S/c27-22-6-3-5-21(19-22)26(31,25-7-1-2-14-29-25)20-12-16-30(17-13-20)15-4-18-34-23-8-10-24(11-9-23)35(28,32)33/h1-3,5-11,14,19-20,31H,4,12-13,15-18H2,(H2,28,32,33)
PDB

KEGG

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 148n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged menin-biotinylated MLL (4 to 15) interaction after 1 hr by HTRF assay

J Med Chem 57: 1543-56 (2014)


Article DOI: 10.1021/jm401868d
BindingDB Entry DOI: 10.7270/Q2XS5ZCB
More data for this
Ligand-Target Pair