Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM50194615'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50194615 (CHEMBL3940264) Show SMILES Fc1ccc([C@H]2CC[C@@H](CC2)NCc2ccn3c(CC4CC4)nnc3c2C(F)(F)F)c(F)c1 |r,wU:5.4,wD:8.11,(20.7,-24.55,;22.03,-23.78,;22.04,-22.24,;23.38,-21.48,;24.7,-22.26,;26.04,-21.5,;26.05,-19.96,;27.38,-19.19,;28.72,-19.97,;28.72,-21.51,;27.37,-22.28,;30.06,-19.2,;30.05,-17.66,;31.38,-16.9,;32.72,-17.67,;34.05,-16.9,;34.05,-15.35,;35.18,-14.31,;36.69,-14.63,;37.72,-13.48,;39.17,-12.99,;38.02,-11.97,;34.55,-12.91,;33.02,-13.08,;32.71,-14.58,;31.38,-15.35,;30.05,-14.58,;30.05,-13.04,;28.72,-15.36,;28.71,-13.81,;24.7,-23.79,;26.04,-24.56,;23.37,-24.56,)| Show InChI InChI=1S/C24H25F5N4/c25-17-5-8-19(20(26)12-17)15-3-6-18(7-4-15)30-13-16-9-10-33-21(11-14-1-2-14)31-32-23(33)22(16)24(27,28)29/h5,8-10,12,14-15,18,30H,1-4,6-7,11,13H2/t15-,18-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	83	n/a	n/a	n/a	n/a
Janssen Research& Development Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated...				J Med Chem 59: 8495-507 (2016) Article DOI: 10.1021/acs.jmedchem.6b00913 BindingDB Entry DOI: 10.7270/Q27M09WC
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