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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM50194665'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50194665
PNG
(CHEMBL3928875)
Show SMILES COC1(CCN(Cc2ccn3c(CC4CC4)nnc3c2C(F)(F)F)CC1)c1ccccc1
Show InChI InChI=1S/C24H27F3N4O/c1-32-23(19-5-3-2-4-6-19)10-13-30(14-11-23)16-18-9-12-31-20(15-17-7-8-17)28-29-22(31)21(18)24(25,26)27/h2-6,9,12,17H,7-8,10-11,13-16H2,1H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 26n/an/an/an/a



Janssen Research& Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated...

J Med Chem 59: 8495-507 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00913
BindingDB Entry DOI: 10.7270/Q27M09WC
More data for this
Ligand-Target Pair