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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50323365'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))
BDBM50323365
PNG
(1,2-dicyclohexyl-3-phenylpropan-1-one O-3-chloroph...)
Show SMILES Clc1cccc(NC(=O)O\N=C(\C(Cc2ccccc2)C2CCCCC2)C2CCCCC2)c1
Show InChI InChI=1S/C28H35ClN2O2/c29-24-17-10-18-25(20-24)30-28(32)33-31-27(23-15-8-3-9-16-23)26(22-13-6-2-7-14-22)19-21-11-4-1-5-12-21/h1,4-5,10-12,17-18,20,22-23,26H,2-3,6-9,13-16,19H2,(H,30,32)/b31-27+
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PC cid
PC sid
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Article
PubMed
16n/an/an/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Antagonist activity at mGLUR5 in rat E17 cells assessed as calcium accumulation by fluorimetry


Bioorg Med Chem Lett 20: 4371-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))
BDBM50323365
PNG
(1,2-dicyclohexyl-3-phenylpropan-1-one O-3-chloroph...)
Show SMILES Clc1cccc(NC(=O)O\N=C(\C(Cc2ccccc2)C2CCCCC2)C2CCCCC2)c1
Show InChI InChI=1S/C28H35ClN2O2/c29-24-17-10-18-25(20-24)30-28(32)33-31-27(23-15-8-3-9-16-23)26(22-13-6-2-7-14-22)19-21-11-4-1-5-12-21/h1,4-5,10-12,17-18,20,22-23,26H,2-3,6-9,13-16,19H2,(H,30,32)/b31-27+
PDB
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UniProtKB/SwissProt

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GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 151n/an/an/an/an/an/a



Gedeon Richter Plc

Curated by ChEMBL


Assay Description
Antagonist activity at mGLUR5 in rat E17 cells assessed as calcium accumulation by fluorimetry


Bioorg Med Chem Lett 20: 4371-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F
More data for this
Ligand-Target Pair