Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' and Ligand = 'BDBM365161'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM365161 (4-(3-(3-methoxybenzyl)-3,4- dihydro-5-oxa-1,2,2a1-...) Show SMILES COc1cccc(CC2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)c1 Show InChI InChI=1S/C24H22N8O2/c1-31-20(7-9-26-31)28-24-25-8-6-19(27-24)16-12-21-29-30-23-17(14-34-22(13-16)32(21)23)10-15-4-3-5-18(11-15)33-2/h3-9,11-13,17H,10,14H2,1-2H3,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				J Med Chem 51: 5009-18 (2008) BindingDB Entry DOI: 10.7270/Q23X88ZR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM365161 (4-(3-(3-methoxybenzyl)-3,4- dihydro-5-oxa-1,2,2a1-...) Show SMILES COc1cccc(CC2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)c1 Show InChI InChI=1S/C24H22N8O2/c1-31-20(7-9-26-31)28-24-25-8-6-19(27-24)16-12-21-29-30-23-17(14-34-22(13-16)32(21)23)10-15-4-3-5-18(11-15)33-2/h3-9,11-13,17H,10,14H2,1-2H3,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.0200	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US10842799 (2020) BindingDB Entry DOI: 10.7270/Q2JQ144N
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM365161 (4-(3-(3-methoxybenzyl)-3,4- dihydro-5-oxa-1,2,2a1-...) Show SMILES COc1cccc(CC2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)c1 Show InChI InChI=1S/C24H22N8O2/c1-31-20(7-9-26-31)28-24-25-8-6-19(27-24)16-12-21-29-30-23-17(14-34-22(13-16)32(21)23)10-15-4-3-5-18(11-15)33-2/h3-9,11-13,17H,10,14H2,1-2H3,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.0200	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US10517878 (2019) BindingDB Entry DOI: 10.7270/Q2NV9MPZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM365161 (4-(3-(3-methoxybenzyl)-3,4- dihydro-5-oxa-1,2,2a1-...) Show SMILES COc1cccc(CC2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)c1 Show InChI InChI=1S/C24H22N8O2/c1-31-20(7-9-26-31)28-24-25-8-6-19(27-24)16-12-21-29-30-23-17(14-34-22(13-16)32(21)23)10-15-4-3-5-18(11-15)33-2/h3-9,11-13,17H,10,14H2,1-2H3,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				J Med Chem 50: 3497-514 (2007) BindingDB Entry DOI: 10.7270/Q2NV9MJ5
					More data for this Ligand-Target Pair