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Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM50505908'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50505908
PNG
(CHEMBL4540969)
Show SMILES CC(C)CC[C@H](NC(=O)c1ccc(C)c(NC(=O)c2cnn(c2N)-c2ccccc2)c1)C(N)=O |r|
Show InChI InChI=1S/C25H30N6O3/c1-15(2)9-12-20(23(27)32)29-24(33)17-11-10-16(3)21(13-17)30-25(34)19-14-28-31(22(19)26)18-7-5-4-6-8-18/h4-8,10-11,13-15,20H,9,12,26H2,1-3H3,(H2,27,32)(H,29,33)(H,30,34)/t20-/m0/s1
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n/an/a 53n/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged P38 alpha MAPK (1 to 360 residues) expressed in Escherichia coli incubated for 60 mins by [gamma-33P]ATP b...

J Med Chem 62: 10757-10782 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01227
BindingDB Entry DOI: 10.7270/Q2NV9NJK
More data for this
Ligand-Target Pair