Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM552551 (2-((6-Methoxy-2-methyl-1,2,3,4-tetrahydroisoquinol...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 0.880 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM552551 (2-((6-Methoxy-2-methyl-1,2,3,4-tetrahydroisoquinol...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB WIPO WO2022098809 | n/a | n/a | 0.880 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Compounds are serially diluted (3-fold in 100% DMSO) across a 384-well polypropylene source plated from column 3 to column 12 and column 13 to colum... | Citation and Details BindingDB Entry DOI: 10.7270/Q2DN4889 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM552551 (2-((6-Methoxy-2-methyl-1,2,3,4-tetrahydroisoquinol...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 517 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of HPK1 in human PBMC assessed as inhibition of SLP76 phosphorylation incubated for 1 hr by ELISA | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00096 BindingDB Entry DOI: 10.7270/Q2B2802B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |