Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase kinase 4' and Ligand = 'BDBM364037'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM364037 (N-[3-(4-aminopyrido[3,2-d]pyrimidin-6-yl)-5-fluoro...) Show SMILES CN1CCN(CCS(=O)(=O)Nc2cc(F)cc(c2)-c2ccc3ncnc(N)c3n2)CC1 Show InChI InChI=1S/C20H24FN7O2S/c1-27-4-6-28(7-5-27)8-9-31(29,30)26-16-11-14(10-15(21)12-16)17-2-3-18-19(25-17)20(22)24-13-23-18/h2-3,10-13,26H,4-9H2,1H3,(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
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