Found 13 hits Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M1' and Ligand = 'BDBM50008072' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | UniProtKB/SwissProt
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 256: 689-94 (1991)
BindingDB Entry DOI: 10.7270/Q25T3J06 |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(RAT) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article
| 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M1, using [3H]- pirenzepine, a radioligand displacement assay in ra... |
Bioorg Med Chem Lett 5: 1813-1818 (1995)
Article DOI: 10.1016/0960-894X(95)00301-9 BindingDB Entry DOI: 10.7270/Q27M07WJ |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | UniProtKB/SwissProt
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| Article PubMed
| 6.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Binding affinity to human cloned muscarinic M1 receptor expressed in CHO cells |
Bioorg Med Chem 16: 3049-58 (2008)
Article DOI: 10.1016/j.bmc.2007.12.036 BindingDB Entry DOI: 10.7270/Q2MS3WJ6 |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | UniProtKB/SwissProt
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| Article PubMed
| 7.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description Binding affinity to muscarinic M1 acetylcholine receptor (unknown origin) |
J Med Chem 58: 560-76 (2015)
Article DOI: 10.1021/jm500860w BindingDB Entry DOI: 10.7270/Q2125VCS |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(RAT) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 9.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona Health Science Center
Curated by PDSP Ki Database
| |
Life Sci 50: 355-63 (1992)
Article DOI: 10.1016/0024-3205(92)90437-t BindingDB Entry DOI: 10.7270/Q2XK8D19 |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(RAT) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| PubMed
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
Sandoz Pharma Ltd.
Curated by ChEMBL
| Assay Description Ability to displace [3H]-pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue. |
J Med Chem 35: 15-27 (1992)
BindingDB Entry DOI: 10.7270/Q29022RV |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(RAT) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article
| n/a | n/a | 4.43E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 recept... |
Bioorg Med Chem Lett 1: 147-150 (1991)
Article DOI: 10.1016/S0960-894X(01)80787-3 BindingDB Entry DOI: 10.7270/Q2513Z3K |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 8.79E+3 | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor |
Bioorg Med Chem Lett 8: 2897-902 (1999)
BindingDB Entry DOI: 10.7270/Q27M08GK |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | n/a | 2.69E+3 | n/a | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description Binding affinity to muscarinic M1 acetylcholine receptor (unknown origin) |
J Med Chem 58: 560-76 (2015)
Article DOI: 10.1021/jm500860w BindingDB Entry DOI: 10.7270/Q2125VCS |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | n/a | 2.69E+3 | n/a | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description Displacement of [3H]NMS from human muscarinic M1 acetylcholine receptor expressed in CHO cell membranes by radioligand binding assay |
J Med Chem 58: 560-76 (2015)
Article DOI: 10.1021/jm500860w BindingDB Entry DOI: 10.7270/Q2125VCS |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | n/a | n/a | 832 | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description Partial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for ... |
J Med Chem 58: 560-76 (2015)
Article DOI: 10.1021/jm500860w BindingDB Entry DOI: 10.7270/Q2125VCS |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Mus musculus) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a |
The University of Toledo
Curated by ChEMBL
| Assay Description Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line |
J Med Chem 40: 1230-46 (1997)
Article DOI: 10.1021/jm960467d BindingDB Entry DOI: 10.7270/Q28916HS |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50008072
((+)-pilocarpine | (3S,4R)-3-ethyl-4-[(1-methyl-1H-...)Show InChI InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology
Curated by ChEMBL
| Assay Description Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 25: 1546-51 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.012 BindingDB Entry DOI: 10.7270/Q2V69M8W |
More data for this Ligand-Target Pair | |