BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M1' and Ligand = 'BDBM50258439'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione \| CHEMBL523685...) Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	6.04E+3	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Muscarinic acetylcholine receptors are family A GPCRs comprised of...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2K64GH0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione \| CHEMBL523685...) Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.04E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activation of rat muscarinic M1 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellul...				J Med Chem 52: 3445-8 (2009) Article DOI: 10.1021/jm900286j BindingDB Entry DOI: 10.7270/Q23B601Q
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione \| CHEMBL523685...) Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation activity at muscarinic M1 receptor				J Med Chem 55: 1445-64 (2012) Article DOI: 10.1021/jm201139r BindingDB Entry DOI: 10.7270/Q25D8SWH
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione \| CHEMBL523685...) Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...				Bioorg Med Chem Lett 20: 5617-22 (2010) Article DOI: 10.1016/j.bmcl.2010.08.042 BindingDB Entry DOI: 10.7270/Q2CR5TK2
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione \| CHEMBL523685...) Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Agonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilization				Bioorg Med Chem Lett 20: 558-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.089 BindingDB Entry DOI: 10.7270/Q2PK0G7M
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair