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Found 1 hit Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M4' and Ligand = 'BDBM50423947'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))		BDBM50423947
PNG
(CHEMBL2313397)
Show SMILES Cc1nc2sc(C(=O)NCc3nccs3)c(N)c2c(C)c1Cl
Show InChI InChI=1S/C14H13ClN4OS2/c1-6-9-11(16)12(22-14(9)19-7(2)10(6)15)13(20)18-5-8-17-3-4-21-8/h3-4H,5,16H2,1-2H3,(H,18,20)
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n/an/an/an/a 249n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated...

Bioorg Med Chem Lett 23: 346-50 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.073
BindingDB Entry DOI: 10.7270/Q2N29Z8S
More data for this
Ligand-Target Pair