Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50178766![]() (2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a | n/a |
Elixir Pharmaceuticals Curated by ChEMBL | Assay Description Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay | J Med Chem 48: 8045-54 (2005) Article DOI: 10.1021/jm050522v BindingDB Entry DOI: 10.7270/Q27D2TPK | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50178766![]() (2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assay | Bioorg Med Chem 17: 7031-41 (2009) Article DOI: 10.1016/j.bmc.2009.07.073 BindingDB Entry DOI: 10.7270/Q21V5FWG | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50178766![]() (2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 652 | n/a | n/a | n/a | n/a | n/a | n/a |
Elixir Pharmaceuticals Curated by ChEMBL | Assay Description Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assay | J Med Chem 48: 8045-54 (2005) Article DOI: 10.1021/jm050522v BindingDB Entry DOI: 10.7270/Q27D2TPK | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |