Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human)) | BDBM50178769![]() ((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of His6-tagged/TEV fused SIRT3 (unknown origin) expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins followed by NAD+ additio... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00017 BindingDB Entry DOI: 10.7270/Q2MK6HQZ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human)) | BDBM50178769![]() ((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human N-terminal His-tagged SIRT3 (122 to 391 residues) expressed in Escherichia coli using Ac-Tyr-Lys-Leu-Lys(Ac)-AMC as substrate pre... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112201 BindingDB Entry DOI: 10.7270/Q26D5XMR | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human)) | BDBM50178769![]() ((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.87E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Elixir Pharmaceuticals Curated by ChEMBL | Assay Description Inhibitory activity against recombinant human SIRT3 expressed in Escherichia coli by fluorimetric assay | J Med Chem 48: 8045-54 (2005) Article DOI: 10.1021/jm050522v BindingDB Entry DOI: 10.7270/Q27D2TPK | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human)) | BDBM50178769![]() ((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of recombinant SIRT3 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay | ACS Med Chem Lett 3: 1050-1053 (2012) Article DOI: 10.1021/ml3002709 BindingDB Entry DOI: 10.7270/Q29C6ZKP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human)) | BDBM50178769![]() ((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sirtris a GSK Company Curated by ChEMBL | Assay Description Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 s... | J Med Chem 56: 3666-79 (2013) Article DOI: 10.1021/jm400204k BindingDB Entry DOI: 10.7270/Q2D50P9C | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human)) | BDBM50178769![]() ((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 8.21E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human N-terminal His-tagged SIRT3 (122 to 391 residues) expressed in Escherichia coli using Ac-Arg-Leu-Ile-Lys(Ac)-AMC as substrate pre... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112201 BindingDB Entry DOI: 10.7270/Q26D5XMR | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human)) | BDBM50178769![]() ((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.28E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of catalytically active human SIRT3 (102 to 399 amino acids) expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-me... | J Med Chem 57: 8340-57 (2014) Article DOI: 10.1021/jm500777s BindingDB Entry DOI: 10.7270/Q2KK9DDH | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |