Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human)) | BDBM50276140![]() (CHEMBL4129995) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >8.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SIRT6 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate additio... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00423 BindingDB Entry DOI: 10.7270/Q2QR51TS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human)) | BDBM50276140![]() (CHEMBL4129995) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of human SIRT6 (1 to 294 residues) expressed in Escherichia coli Rosetta (DE3) using H3K9AcWW as substrate preincubated for 15 mins follow... | Bioorg Med Chem Lett 28: 2375-2378 (2018) Article DOI: 10.1016/j.bmcl.2018.06.030 BindingDB Entry DOI: 10.7270/Q2GX4F1M | |||||||||||
More data for this Ligand-Target Pair |