Found 2 hits Enz. Inhib. hit(s) with Target = 'Neuropeptide Y receptor type 4' and Ligand = 'BDBM50528178' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50528178
(CHEMBL4468261)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C116H182N34O24/c1-9-65(7)93(117)109(171)141-81-45-47-91(155)129-49-13-11-22-76(100(162)148-88(62-70-35-43-74(154)44-36-70)106(168)138-80(26-18-54-134-116(127)128)102(164)146-86(58-64(5)6)104(166)136-78(24-16-52-132-114(123)124)98(160)144-84(96(120)158)60-68-31-39-72(152)40-32-68)140-108(170)90-28-20-56-150(90)112(174)82(142-110(172)94(118)66(8)10-2)46-48-92(156)130-50-14-12-21-75(139-107(169)89-27-19-55-149(89)111(81)173)99(161)147-87(61-69-33-41-73(153)42-34-69)105(167)137-79(25-17-53-133-115(125)126)101(163)145-85(57-63(3)4)103(165)135-77(23-15-51-131-113(121)122)97(159)143-83(95(119)157)59-67-29-37-71(151)38-30-67/h29-44,63-66,75-90,93-94,151-154H,9-28,45-62,117-118H2,1-8H3,(H2,119,157)(H2,120,158)(H,129,155)(H,130,156)(H,135,165)(H,136,166)(H,137,167)(H,138,168)(H,139,169)(H,140,170)(H,141,171)(H,142,172)(H,143,159)(H,144,160)(H,145,163)(H,146,164)(H,147,161)(H,148,162)(H4,121,122,131)(H4,123,124,132)(H4,125,126,133)(H4,127,128,134)/t65-,66-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,93-,94-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y4R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by ... |
J Med Chem 63: 5274-5286 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00027
BindingDB Entry DOI: 10.7270/Q2RB782R |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50528178
(CHEMBL4468261)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C116H182N34O24/c1-9-65(7)93(117)109(171)141-81-45-47-91(155)129-49-13-11-22-76(100(162)148-88(62-70-35-43-74(154)44-36-70)106(168)138-80(26-18-54-134-116(127)128)102(164)146-86(58-64(5)6)104(166)136-78(24-16-52-132-114(123)124)98(160)144-84(96(120)158)60-68-31-39-72(152)40-32-68)140-108(170)90-28-20-56-150(90)112(174)82(142-110(172)94(118)66(8)10-2)46-48-92(156)130-50-14-12-21-75(139-107(169)89-27-19-55-149(89)111(81)173)99(161)147-87(61-69-33-41-73(153)42-34-69)105(167)137-79(25-17-53-133-115(125)126)101(163)145-85(57-63(3)4)103(165)135-77(23-15-51-131-113(121)122)97(159)143-83(95(119)157)59-67-29-37-71(151)38-30-67/h29-44,63-66,75-90,93-94,151-154H,9-28,45-62,117-118H2,1-8H3,(H2,119,157)(H2,120,158)(H,129,155)(H,130,156)(H,135,165)(H,136,166)(H,137,167)(H,138,168)(H,139,169)(H,140,170)(H,141,171)(H,142,172)(H,143,159)(H,144,160)(H,145,163)(H,146,164)(H,147,161)(H,148,162)(H4,121,122,131)(H4,123,124,132)(H4,125,126,133)(H4,127,128,134)/t65-,66-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,93-,94-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Agonist activity at Y4R in human HEK293T cells assessed as increase in beta-arrestin recruitment incubated for 30 mins by Hoechst 33342 dye based flu... |
J Med Chem 63: 5274-5286 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00027
BindingDB Entry DOI: 10.7270/Q2RB782R |
More data for this
Ligand-Target Pair | |
Search and Browse
