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Found 1 hit Enz. Inhib. hit(s) with Target = 'Neutrophil elastase' and Ligand = 'BDBM50023516'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neutrophil elastase


(Homo sapiens (Human))		BDBM50023516
PNG
(3-[5-Benzoyl-2-(2,2-dimethyl-propionyloxy)-phenyl]...)
Show SMILES CC(Cc1cc(ccc1OC(=O)C(C)(C)C)C(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C22H24O5/c1-14(20(24)25)12-17-13-16(19(23)15-8-6-5-7-9-15)10-11-18(17)27-21(26)22(2,3)4/h5-11,13-14H,12H2,1-4H3,(H,24,25)
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PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against human leukocyte elastase at 10e-6 M

J Med Chem 31: 1052-61 (1988)


BindingDB Entry DOI: 10.7270/Q2PC31DJ
More data for this
Ligand-Target Pair