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Found 1 hit Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase' and Ligand = 'BDBM398290'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398290
PNG
(US10323018, Compound I-19)
Show SMILES CCOc1nc(nc2cc(ccc12)C(=O)NCCCc1cncnc1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H22FN5O2/c1-2-32-24-20-10-7-18(23(31)28-11-3-4-16-13-26-15-27-14-16)12-21(20)29-22(30-24)17-5-8-19(25)9-6-17/h5-10,12-15H,2-4,11H2,1H3,(H,28,31)
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n/an/a<10n/an/an/an/an/an/a



Wyeth Research



Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

Bioorg Med Chem Lett 19: 5225-8 (2009)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair