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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase' and Ligand = 'BDBM398331'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398331
PNG
(US10323018, Compound I-60)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NC1CC(C1)c1ncc[nH]1)-c1ccc(F)cc1 |(6.52,-3.08,;5.19,-3.85,;3.85,-3.08,;3.85,-1.54,;5.19,-.77,;5.19,.77,;3.85,1.54,;2.52,.77,;1.18,1.54,;-.15,.77,;-.15,-.77,;1.18,-1.54,;2.52,-.77,;-1.48,1.54,;-1.48,3.08,;-2.82,.77,;-4.15,1.54,;-5.48,.77,;-6.82,1.54,;-5.48,2.31,;-8.15,.77,;-9.62,1.25,;-10.52,,;-9.62,-1.25,;-8.15,-.77,;6.52,1.54,;7.85,.77,;9.19,1.54,;9.19,3.08,;10.52,3.85,;7.85,3.85,;6.52,3.08,)|
Show InChI InChI=1S/C25H23FN4O2/c1-2-32-23-14-21(15-3-6-18(26)7-4-15)30-22-13-16(5-8-20(22)23)25(31)29-19-11-17(12-19)24-27-9-10-28-24/h3-10,13-14,17,19H,2,11-12H2,1H3,(H,27,28)(H,29,31)
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n/an/a<10n/an/an/an/an/an/a



Wyeth Research



Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

Bioorg Med Chem Lett 19: 5225-8 (2009)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair