Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2' and Ligand = 'BDBM325480'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325480 ((S)-1-methyl-3-((2-(4-(4-(1- (pentan-3-yl)-1H-pyra...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN[C@H]2CCN(C)C2=O)c1 |r| Show InChI InChI=1S/C24H31N9O/c1-4-19(5-2)32-15-18(13-28-32)23-22-6-8-26-33(22)16-21(29-23)17-12-27-31(14-17)11-9-25-20-7-10-30(3)24(20)34/h6,8,12-16,19-20,25H,4-5,7,9-11H2,1-3H3/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020) BindingDB Entry DOI: 10.7270/Q2CC13R9
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325480 ((S)-1-methyl-3-((2-(4-(4-(1- (pentan-3-yl)-1H-pyra...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN[C@H]2CCN(C)C2=O)c1 |r| Show InChI InChI=1S/C24H31N9O/c1-4-19(5-2)32-15-18(13-28-32)23-22-6-8-26-33(22)16-21(29-23)17-12-27-31(14-17)11-9-25-20-7-10-30(3)24(20)34/h6,8,12-16,19-20,25H,4-5,7,9-11H2,1-3H3/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021) BindingDB Entry DOI: 10.7270/Q2T156RN
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325480 ((S)-1-methyl-3-((2-(4-(4-(1- (pentan-3-yl)-1H-pyra...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN[C@H]2CCN(C)C2=O)c1 |r| Show InChI InChI=1S/C24H31N9O/c1-4-19(5-2)32-15-18(13-28-32)23-22-6-8-26-33(22)16-21(29-23)17-12-27-31(14-17)11-9-25-20-7-10-30(3)24(20)34/h6,8,12-16,19-20,25H,4-5,7,9-11H2,1-3H3/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair