Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2' and Ligand = 'BDBM325484'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325484 ((1-(2-(4-(4-(1-(pentan-3-yl)- 1H-pyrazol-4- yl)pyr...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN2CCC(CO)CC2)c1 Show InChI InChI=1S/C25H34N8O/c1-3-22(4-2)32-16-21(14-28-32)25-24-5-8-26-33(24)17-23(29-25)20-13-27-31(15-20)12-11-30-9-6-19(18-34)7-10-30/h5,8,13-17,19,22,34H,3-4,6-7,9-12,18H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10189845 (2019) BindingDB Entry DOI: 10.7270/Q2Z03B7Q
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325484 ((1-(2-(4-(4-(1-(pentan-3-yl)- 1H-pyrazol-4- yl)pyr...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN2CCC(CO)CC2)c1 Show InChI InChI=1S/C25H34N8O/c1-3-22(4-2)32-16-21(14-28-32)25-24-5-8-26-33(24)17-23(29-25)20-13-27-31(15-20)12-11-30-9-6-19(18-34)7-10-30/h5,8,13-17,19,22,34H,3-4,6-7,9-12,18H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC.; CELGENE CORPORATION US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US11028093 (2021) BindingDB Entry DOI: 10.7270/Q2T156RN
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM325484 ((1-(2-(4-(4-(1-(pentan-3-yl)- 1H-pyrazol-4- yl)pyr...) Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN2CCC(CO)CC2)c1 Show InChI InChI=1S/C25H34N8O/c1-3-22(4-2)32-16-21(14-28-32)25-24-5-8-26-33(24)17-23(29-25)20-13-27-31(15-20)12-11-30-9-6-19(18-34)7-10-30/h5,8,13-17,19,22,34H,3-4,6-7,9-12,18H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc.; Celgene Corporation US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US10730880 (2020) BindingDB Entry DOI: 10.7270/Q2CC13R9
					More data for this Ligand-Target Pair