Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2' and Ligand = 'BDBM329930'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329930 (US10463675, Example 13 | US10980815, Ex. No. 13 | ...) Show SMILES CCNC(=O)c1ccc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)CC#N)cc1 |r,THB:24:23:16.17.22:20.19| Show InChI InChI=1S/C22H25N7O2/c1-2-24-21(31)15-3-5-16(6-4-15)26-22-25-12-10-19(27-22)28-13-17-7-8-18(14-28)29(17)20(30)9-11-23/h3-6,10,12,17-18H,2,7-9,13-14H2,1H3,(H,24,31)(H,25,26,27)/t17-,18+	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...				US Patent US9663526 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KVD
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329930 (US10463675, Example 13 | US10980815, Ex. No. 13 | ...) Show SMILES CCNC(=O)c1ccc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)CC#N)cc1 |r,THB:24:23:16.17.22:20.19| Show InChI InChI=1S/C22H25N7O2/c1-2-24-21(31)15-3-5-16(6-4-15)26-22-25-12-10-19(27-22)28-13-17-7-8-18(14-28)29(17)20(30)9-11-23/h3-6,10,12,17-18H,2,7-9,13-14H2,1H3,(H,24,31)(H,25,26,27)/t17-,18+	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PC35J0
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329930 (US10463675, Example 13 | US10980815, Ex. No. 13 | ...) Show SMILES CCNC(=O)c1ccc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)CC#N)cc1 |r,THB:24:23:16.17.22:20.19| Show InChI InChI=1S/C22H25N7O2/c1-2-24-21(31)15-3-5-16(6-4-15)26-22-25-12-10-19(27-22)28-13-17-7-8-18(14-28)29(17)20(30)9-11-23/h3-6,10,12,17-18H,2,7-9,13-14H2,1H3,(H,24,31)(H,25,26,27)/t17-,18+	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...				US Patent US10980815 (2021) BindingDB Entry DOI: 10.7270/Q2XD14SG
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329930 (US10463675, Example 13 | US10980815, Ex. No. 13 | ...) Show SMILES CCNC(=O)c1ccc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)CC#N)cc1 |r,THB:24:23:16.17.22:20.19| Show InChI InChI=1S/C22H25N7O2/c1-2-24-21(31)15-3-5-16(6-4-15)26-22-25-12-10-19(27-22)28-13-17-7-8-18(14-28)29(17)20(30)9-11-23/h3-6,10,12,17-18H,2,7-9,13-14H2,1H3,(H,24,31)(H,25,26,27)/t17-,18+	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...				US Patent US10463675 (2019) BindingDB Entry DOI: 10.7270/Q2VT1VGN
					More data for this Ligand-Target Pair