Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2' and Ligand = 'BDBM329943'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329943 (US10463675, Example 26 | US10980815, Ex. No. 26 | ...) Show SMILES CC(C)(C#N)c1ccc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)[C@@H]2CC2(F)F)cn1 |r,THB:24:23:16.17.22:20.19| Show InChI InChI=1S/C23H25F2N7O/c1-22(2,13-26)18-6-3-14(10-28-18)29-21-27-8-7-19(30-21)31-11-15-4-5-16(12-31)32(15)20(33)17-9-23(17,24)25/h3,6-8,10,15-17H,4-5,9,11-12H2,1-2H3,(H,27,29,30)/t15-,16+,17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...				US Patent US9663526 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KVD
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329943 (US10463675, Example 26 | US10980815, Ex. No. 26 | ...) Show SMILES CC(C)(C#N)c1ccc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)[C@@H]2CC2(F)F)cn1 |r,THB:24:23:16.17.22:20.19| Show InChI InChI=1S/C23H25F2N7O/c1-22(2,13-26)18-6-3-14(10-28-18)29-21-27-8-7-19(30-21)31-11-15-4-5-16(12-31)32(15)20(33)17-9-23(17,24)25/h3,6-8,10,15-17H,4-5,9,11-12H2,1-2H3,(H,27,29,30)/t15-,16+,17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PC35J0
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329943 (US10463675, Example 26 | US10980815, Ex. No. 26 | ...) Show SMILES CC(C)(C#N)c1ccc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)[C@@H]2CC2(F)F)cn1 |r,THB:24:23:16.17.22:20.19| Show InChI InChI=1S/C23H25F2N7O/c1-22(2,13-26)18-6-3-14(10-28-18)29-21-27-8-7-19(30-21)31-11-15-4-5-16(12-31)32(15)20(33)17-9-23(17,24)25/h3,6-8,10,15-17H,4-5,9,11-12H2,1-2H3,(H,27,29,30)/t15-,16+,17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...				US Patent US10980815 (2021) BindingDB Entry DOI: 10.7270/Q2XD14SG
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329943 (US10463675, Example 26 | US10980815, Ex. No. 26 | ...) Show SMILES CC(C)(C#N)c1ccc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)[C@@H]2CC2(F)F)cn1 |r,THB:24:23:16.17.22:20.19| Show InChI InChI=1S/C23H25F2N7O/c1-22(2,13-26)18-6-3-14(10-28-18)29-21-27-8-7-19(30-21)31-11-15-4-5-16(12-31)32(15)20(33)17-9-23(17,24)25/h3,6-8,10,15-17H,4-5,9,11-12H2,1-2H3,(H,27,29,30)/t15-,16+,17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...				US Patent US10463675 (2019) BindingDB Entry DOI: 10.7270/Q2VT1VGN
					More data for this Ligand-Target Pair