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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2' and Ligand = 'BDBM425122'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM425122
PNG
(US10519153, Example 9-21)
Show SMILES CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@@H](CN3CC[C@@H](C3)N(C)C)N(Cc2[nH]1)C(C)C |r|
Show InChI InChI=1S/C31H38FN7O/c1-6-19-12-29(40)25(32)14-24(19)20-7-8-23-26(11-20)35-36-30(23)31-33-27-13-22(39(18(2)3)17-28(27)34-31)16-38-10-9-21(15-38)37(4)5/h7-8,11-12,14,18,21-22,40H,6,9-10,13,15-17H2,1-5H3/b31-30-/t21-,22-/m0/s1
PDB

KEGG

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US Patent
 1n/an/an/an/an/an/an/an/a



Theravance Biopharma R&D IP, LLC

US Patent


Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...

US Patent US10519153 (2019)


BindingDB Entry DOI: 10.7270/Q2DB8482
More data for this
Ligand-Target Pair