Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2 [5-1181]' and Ligand = 'BDBM50519532'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 [5-1181] (Mus musculus)	BDBM50519532 (CHEMBL4443834) Show SMILES CNC(=O)c1cnc(Nc2cc(C)c(F)cn2)cc1Nc1cccc(-c2nnc(C)o2)c1OC Show InChI InChI=1S/C23H22FN7O3/c1-12-8-19(27-11-16(12)24)29-20-9-18(15(10-26-20)22(32)25-3)28-17-7-5-6-14(21(17)33-4)23-31-30-13(2)34-23/h5-11H,1-4H3,(H,25,32)(H2,26,27,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...				J Med Chem 62: 8973-8995 (2019) Article DOI: 10.1021/acs.jmedchem.9b00444 BindingDB Entry DOI: 10.7270/Q2930XJS
					More data for this Ligand-Target Pair