Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2 [580-1182,C936A,C1142A]' and Ligand = 'BDBM493091'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 [580-1182,C936A,C1142A] (Homo sapiens (Human))	BDBM493091 (2-((1r,4r)-4-(2-(4-Chloro-1H-pyrazol-3-yl)imidazo[...) Show SMILES Clc1c[nH]nc1-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:21.25,wD:18.21,(-1.66,3.23,;-3.17,2.91,;-4.31,3.94,;-5.64,3.17,;-5.32,1.66,;-3.79,1.5,;-3.02,.17,;-3.65,-1.24,;-2.5,-2.27,;-2.5,-3.81,;-1.17,-4.58,;.16,-3.81,;1.63,-4.29,;2.53,-3.04,;1.63,-1.8,;.16,-2.27,;-1.17,-1.5,;-1.49,0,;-.46,1.15,;1.05,.83,;2.08,1.97,;1.6,3.44,;2.63,4.58,;4.14,4.26,;5.64,3.94,;.09,3.76,;-.94,2.61,)| Show InChI InChI=1S/C19H16ClN7/c20-14-9-24-26-16(14)19-25-15-10-23-18-13(6-8-22-18)17(15)27(19)12-3-1-11(2-4-12)5-7-21/h6,8-12H,1-5H2/b19-16+/t11-,12-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...				US Patent US10981911 (2021) BindingDB Entry DOI: 10.7270/Q27P92G6
					More data for this Ligand-Target Pair