BindingDB PrimarySearch

Found 11 hits Enz. Inhib. hit(s) with Target = 'Orexin receptor type 2' and Ligand = 'BDBM163879'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163879 (US9062078, 11 \| US9062078, 12A \| US9062078, 12B \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163879 (US9062078, 11 \| US9062078, 12A \| US9062078, 12B \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5	-49.8	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
JANSSEN PHARMACEUTICA NV US Patent					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163879 (US9062078, 11 \| US9062078, 12A \| US9062078, 12B \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5	-49.8	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
JANSSEN PHARMACEUTICA NV US Patent					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163879 (US9062078, 11 \| US9062078, 12A \| US9062078, 12B \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	-47.5	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
JANSSEN PHARMACEUTICA NV US Patent					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163879 (US9062078, 11 \| US9062078, 12A \| US9062078, 12B \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	-47.5	n/a	n/a	n/a	n/a	n/a	n/a	40
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...				US Patent US9475819 (2016) BindingDB Entry DOI: 10.7270/Q2DZ0771
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163879 (US9062078, 11 \| US9062078, 12A \| US9062078, 12B \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	-47.5	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
JANSSEN PHARMACEUTICA NV US Patent					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163879 (US9062078, 11 \| US9062078, 12A \| US9062078, 12B \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163879 (US9062078, 11 \| US9062078, 12A \| US9062078, 12B \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human OX2R				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00085 BindingDB Entry DOI: 10.7270/Q2348Q4F
TBA					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163879 (US9062078, 11 \| US9062078, 12A \| US9062078, 12B \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	339	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...				US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163879 (US9062078, 11 \| US9062078, 12A \| US9062078, 12B \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	339	-38.8	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...				US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3
JANSSEN PHARMACEUTICA NV US Patent					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM163879 (US9062078, 11 \| US9062078, 12A \| US9062078, 12B \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	339	-38.8	n/a	n/a	n/a	n/a	n/a	n/a	40
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM
JANSSEN PHARMACEUTICA NV US Patent					More data for this Ligand-Target Pair