BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with Target = 'P2X purinoceptor 4' and Ligand = 'BDBM50506159'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Bayer AG Curated by ChEMBL					Assay Description Antagonist activity at human P2X4 receptor tranfected in human HEK293 cells at -60 mv holding potential by Whole cell patch-clamp method				J Med Chem 62: 11194-11217 (2019) Article DOI: 10.1021/acs.jmedchem.9b01304 BindingDB Entry DOI: 10.7270/Q2M048RW
Bayer AG Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
University of East Anglia Curated by ChEMBL					Assay Description Antagonist activity at human P2X4R transfected in HEK293 cells assessed as inhibition of ATP-evoked current by patch clamp assay				J Nat Prod 82: 2559-2567 (2019) Article DOI: 10.1021/acs.jnatprod.9b00410 BindingDB Entry DOI: 10.7270/Q2JW8JBP
University of East Anglia Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
University of East Anglia Curated by ChEMBL					Assay Description Antagonist activity at human P2X4R transfected in HEK293 cells assessed as inhibition of ATP-evoked current by patch clamp assay				J Nat Prod 82: 2559-2567 (2019) Article DOI: 10.1021/acs.jnatprod.9b00410 BindingDB Entry DOI: 10.7270/Q2JW8JBP
University of East Anglia Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
University of East Anglia Curated by ChEMBL					Assay Description Antagonist activity at human P2X4R transfected in 1321N1 cells assessed as inhibition of ATP-mediated calcium influx measured after 10 mins by Fura-2...				J Nat Prod 82: 2559-2567 (2019) Article DOI: 10.1021/acs.jnatprod.9b00410 BindingDB Entry DOI: 10.7270/Q2JW8JBP
University of East Anglia Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
University of East Anglia Curated by ChEMBL					Assay Description Antagonist activity at human P2X4R transfected in 1321N1 cells assessed as inhibition of ATP-mediated calcium influx measured after 10 mins by Fura-2...				J Nat Prod 82: 2559-2567 (2019) Article DOI: 10.1021/acs.jnatprod.9b00410 BindingDB Entry DOI: 10.7270/Q2JW8JBP
University of East Anglia Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
Bayer AG Curated by ChEMBL					Assay Description Antagonist activity at human P2X4 receptor tranfected in human HEK293 cells assessed as inhibition of ATP-induced calcium influx by Fluo2-AM staining...				J Med Chem 62: 11194-11217 (2019) Article DOI: 10.1021/acs.jmedchem.9b01304 BindingDB Entry DOI: 10.7270/Q2M048RW
Bayer AG Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	904	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114491 BindingDB Entry DOI: 10.7270/Q2BG2T1P
TBA					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of East Anglia Curated by ChEMBL					Assay Description Antagonist activity at human P2X4R transfected in HEK293 cells assessed as inhibition of ATP-mediated calcium influx measured after 10 mins by YOPRO-...				J Nat Prod 82: 2559-2567 (2019) Article DOI: 10.1021/acs.jnatprod.9b00410 BindingDB Entry DOI: 10.7270/Q2JW8JBP
University of East Anglia Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of East Anglia Curated by ChEMBL					Assay Description Antagonist activity at human P2X4R transfected in HEK293 cells assessed as inhibition of ATP-mediated calcium influx measured after 10 mins by YOPRO-...				J Nat Prod 82: 2559-2567 (2019) Article DOI: 10.1021/acs.jnatprod.9b00410 BindingDB Entry DOI: 10.7270/Q2JW8JBP
University of East Anglia Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of East Anglia Curated by ChEMBL					Assay Description Antagonist activity at human P2X4R transfected in 1321N1 cells				J Nat Prod 82: 2559-2567 (2019) Article DOI: 10.1021/acs.jnatprod.9b00410 BindingDB Entry DOI: 10.7270/Q2JW8JBP
University of East Anglia Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of East Anglia Curated by ChEMBL					Assay Description Antagonist activity at human P2X4R transfected in 1321N1 cells				J Nat Prod 82: 2559-2567 (2019) Article DOI: 10.1021/acs.jnatprod.9b00410 BindingDB Entry DOI: 10.7270/Q2JW8JBP
University of East Anglia Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50506159 (CHEMBL1532400) Show SMILES CC(C)c1cc(Br)c(NC(=O)Nc2cccnc2)c(Br)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01197 BindingDB Entry DOI: 10.7270/Q2RX9H1T
TBA					More data for this Ligand-Target Pair