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Found 16 hits Enz. Inhib. hit(s) with Target = 'P2X purinoceptor 7' and Ligand = 'BDBM173268'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
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3.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)


BindingDB Entry DOI: 10.7270/Q2B56MTX
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
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US Patent
3.5n/an/an/an/an/an/an/an/a



Universita degli Studi di Milano



Assay Description
Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...


Bioorg Med Chem 17: 5834-56 (2009)


BindingDB Entry DOI: 10.7270/Q21Z46SW
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
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3.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)


BindingDB Entry DOI: 10.7270/Q2B56MTX
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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3.5n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9096596 (2015)


BindingDB Entry DOI: 10.7270/Q2SJ1JC6
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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25.1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9096596 (2015)


BindingDB Entry DOI: 10.7270/Q2SJ1JC6
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
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25.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)


BindingDB Entry DOI: 10.7270/Q2B56MTX
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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25.1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)


BindingDB Entry DOI: 10.7270/Q2B56MTX
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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25.1n/an/an/an/an/an/an/an/a



Universita degli Studi di Milano



Assay Description
Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...


Bioorg Med Chem 17: 5834-56 (2009)


BindingDB Entry DOI: 10.7270/Q21Z46SW
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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US Patent
n/an/a 5.90n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)


BindingDB Entry DOI: 10.7270/Q2B56MTX
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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US Patent
n/an/a 5.90n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)


BindingDB Entry DOI: 10.7270/Q2B56MTX
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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antibodypedia
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US Patent
n/an/a 5.90n/an/an/an/a7.4n/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high gluc...


US Patent US9096596 (2015)


BindingDB Entry DOI: 10.7270/Q2SJ1JC6
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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n/an/a 5.90n/an/an/an/an/an/a



Universita degli Studi di Milano



Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Bioorg Med Chem 17: 5834-56 (2009)


BindingDB Entry DOI: 10.7270/Q21Z46SW
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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n/an/a 338n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)


BindingDB Entry DOI: 10.7270/Q2B56MTX
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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n/an/a 338n/an/an/an/an/an/a



Universita degli Studi di Milano



Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


Bioorg Med Chem 17: 5834-56 (2009)


BindingDB Entry DOI: 10.7270/Q21Z46SW
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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n/an/a 338n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)


BindingDB Entry DOI: 10.7270/Q2B56MTX
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Rattus norvegicus (Rat))
BDBM173268
PNG
(US10323032, Example 20 | US9096596, 20 | US9604982...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
PDB

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n/an/a 338n/an/an/an/a7.4n/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high gluc...


US Patent US9096596 (2015)


BindingDB Entry DOI: 10.7270/Q2SJ1JC6
More data for this
Ligand-Target Pair