Found 6 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform' and Ligand = 'BDBM118234' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM118234
(US8653092, 1)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H31N5O4/c1-16-11-18(12-25-22(16)31-2)28-8-4-21-20(14-28)23(27-15-26-21)33-19-3-7-29(13-19)24(30)17-5-9-32-10-6-17/h11-12,15,17,19H,3-10,13-14H2,1-2H3/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
Test of Lipid Kinase Activity: The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The fi... |
US Patent US8653092 (2014)
BindingDB Entry DOI: 10.7270/Q2M61HXZ |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM118234
(US8653092, 1)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H31N5O4/c1-16-11-18(12-25-22(16)31-2)28-8-4-21-20(14-28)23(27-15-26-21)33-19-3-7-29(13-19)24(30)17-5-9-32-10-6-17/h11-12,15,17,19H,3-10,13-14H2,1-2H3/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta (unknown origin) using phosphatidylinositol as substrate after 90 mins by scintillation proximity assay |
Bioorg Med Chem 26: 2410-2419 (2018)
Article DOI: 10.1016/j.bmc.2018.03.042
BindingDB Entry DOI: 10.7270/Q2PN988P |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM118234
(US8653092, 1)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H31N5O4/c1-16-11-18(12-25-22(16)31-2)28-8-4-21-20(14-28)23(27-15-26-21)33-19-3-7-29(13-19)24(30)17-5-9-32-10-6-17/h11-12,15,17,19H,3-10,13-14H2,1-2H3/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of [33P]ATP by Scintillation pro... |
Bioorg Med Chem 27: 1056-1064 (2019)
Article DOI: 10.1016/j.bmc.2019.02.001
BindingDB Entry DOI: 10.7270/Q20868PX |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM118234
(US8653092, 1)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H31N5O4/c1-16-11-18(12-25-22(16)31-2)28-8-4-21-20(14-28)23(27-15-26-21)33-19-3-7-29(13-19)24(30)17-5-9-32-10-6-17/h11-12,15,17,19H,3-10,13-14H2,1-2H3/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins by Alexa Fluor647-labelled ADP tracer based ... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293
BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Mus musculus (Mouse)) | BDBM118234
(US8653092, 1)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H31N5O4/c1-16-11-18(12-25-22(16)31-2)28-8-4-21-20(14-28)23(27-15-26-21)33-19-3-7-29(13-19)24(30)17-5-9-32-10-6-17/h11-12,15,17,19H,3-10,13-14H2,1-2H3/t19-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta in Balb/c mouse splenocytes assessed as reduction in anti-IgM stimulated CD86 expression pretreated for 1 hr followed by anti... |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293
BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM118234
(US8653092, 1)Show SMILES COc1ncc(cc1C)N1CCc2ncnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)c2C1 |r| Show InChI InChI=1S/C24H31N5O4/c1-16-11-18(12-25-22(16)31-2)28-8-4-21-20(14-28)23(27-15-26-21)33-19-3-7-29(13-19)24(30)17-5-9-32-10-6-17/h11-12,15,17,19H,3-10,13-14H2,1-2H3/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 143 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM) |
ACS Med Chem Lett 8: 975-980 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00293
BindingDB Entry DOI: 10.7270/Q2SX6GR0 |
More data for this
Ligand-Target Pair | |
Search and Browse
