Found 2 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform' and Ligand = 'BDBM204070' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM204070
![PNG](/data/jpeg/tenK20/BindingDB_204070.png) (US9539260, D35 | US9539260, D36 | US9763952, Examp...)Show SMILES COC1CCC(CC1)C(=O)N1CC[C@@H](C1)Oc1ccc2OCCN(c3cnc(OC)c(c3)C#N)c2c1 |r,wD:13.16,(8.9,-5.23,;8.51,-3.74,;7.02,-3.35,;5.93,-4.43,;4.44,-4.04,;4.04,-2.55,;5.13,-1.46,;6.62,-1.86,;2.56,-2.15,;2.16,-.66,;1.47,-3.24,;.56,-4.48,;-.9,-4.01,;-.9,-2.47,;.56,-1.99,;-2.24,-1.7,;-3.57,-2.47,;-3.57,-4.01,;-4.9,-4.78,;-6.24,-4.01,;-7.57,-4.78,;-8.9,-4.01,;-8.9,-2.47,;-7.57,-1.7,;-7.57,-.16,;-8.9,.61,;-8.9,2.15,;-7.57,2.92,;-7.57,4.46,;-6.24,5.23,;-6.24,2.15,;-6.24,.61,;-4.9,2.92,;-3.57,3.69,;-6.24,-2.47,;-4.9,-1.7,)| Show InChI InChI=1S/C27H32N4O5/c1-33-21-5-3-18(4-6-21)27(32)30-10-9-23(17-30)36-22-7-8-25-24(14-22)31(11-12-35-25)20-13-19(15-28)26(34-2)29-16-20/h7-8,13-14,16,18,21,23H,3-6,9-12,17H2,1-2H3/t18?,21?,23-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| |
US Patent US9763952 (2017)
BindingDB Entry DOI: 10.7270/Q2V40X9Z |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM204070
![PNG](/data/jpeg/tenK20/BindingDB_204070.png) (US9539260, D35 | US9539260, D36 | US9763952, Examp...)Show SMILES COC1CCC(CC1)C(=O)N1CC[C@@H](C1)Oc1ccc2OCCN(c3cnc(OC)c(c3)C#N)c2c1 |r,wD:13.16,(8.9,-5.23,;8.51,-3.74,;7.02,-3.35,;5.93,-4.43,;4.44,-4.04,;4.04,-2.55,;5.13,-1.46,;6.62,-1.86,;2.56,-2.15,;2.16,-.66,;1.47,-3.24,;.56,-4.48,;-.9,-4.01,;-.9,-2.47,;.56,-1.99,;-2.24,-1.7,;-3.57,-2.47,;-3.57,-4.01,;-4.9,-4.78,;-6.24,-4.01,;-7.57,-4.78,;-8.9,-4.01,;-8.9,-2.47,;-7.57,-1.7,;-7.57,-.16,;-8.9,.61,;-8.9,2.15,;-7.57,2.92,;-7.57,4.46,;-6.24,5.23,;-6.24,2.15,;-6.24,.61,;-4.9,2.92,;-3.57,3.69,;-6.24,-2.47,;-4.9,-1.7,)| Show InChI InChI=1S/C27H32N4O5/c1-33-21-5-3-18(4-6-21)27(32)30-10-9-23(17-30)36-22-7-8-25-24(14-22)31(11-12-35-25)20-13-19(15-28)26(34-2)29-16-20/h7-8,13-14,16,18,21,23H,3-6,9-12,17H2,1-2H3/t18?,21?,23-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | 25 |
NOVARTIS AG
US Patent
| Assay Description Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1... |
US Patent US9539260 (2017)
BindingDB Entry DOI: 10.7270/Q2W37TH1 |
More data for this Ligand-Target Pair | |