Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform' and Ligand = 'BDBM489246'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489246 (2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCCCC2=O)nc1C |r| Show InChI InChI=1S/C28H32N6O4S2/c1-16-26(39-28(30-16)32-22-7-6-8-23(31-22)33-12-5-4-9-24(33)35)19-13-20-15-34(17(2)18-10-11-18)27(36)25(20)21(14-19)40(37,38)29-3/h6-8,13-14,17-18,29H,4-5,9-12,15H2,1-3H3,(H,30,31,32)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...				US Patent US10961236 (2021) BindingDB Entry DOI: 10.7270/Q2M90CS5
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489246 (2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCCCC2=O)nc1C |r| Show InChI InChI=1S/C28H32N6O4S2/c1-16-26(39-28(30-16)32-22-7-6-8-23(31-22)33-12-5-4-9-24(33)35)19-13-20-15-34(17(2)18-10-11-18)27(36)25(20)21(14-19)40(37,38)29-3/h6-8,13-14,17-18,29H,4-5,9-12,15H2,1-3H3,(H,30,31,32)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00434 BindingDB Entry DOI: 10.7270/Q24Q7ZVJ
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM489246 (2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCCCC2=O)nc1C |r| Show InChI InChI=1S/C28H32N6O4S2/c1-16-26(39-28(30-16)32-22-7-6-8-23(31-22)33-12-5-4-9-24(33)35)19-13-20-15-34(17(2)18-10-11-18)27(36)25(20)21(14-19)40(37,38)29-3/h6-8,13-14,17-18,29H,4-5,9-12,15H2,1-3H3,(H,30,31,32)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PI3Kdelta in anti-IgM-stimulated human JeKo-1 cells assessed as inhibition of AKT phosphorylation at Ser473 residue incubated for 60 mi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00434 BindingDB Entry DOI: 10.7270/Q24Q7ZVJ
					More data for this Ligand-Target Pair