Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform' and Ligand = 'BDBM489247'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Mus musculus (Mouse))	BDBM489247 (2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...) Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C |r| Show InChI InChI=1S/C27H30N6O5S2/c1-15-25(39-27(29-15)31-21-5-4-6-22(30-21)32-9-10-38-14-23(32)34)18-11-19-13-33(16(2)17-7-8-17)26(35)24(19)20(12-18)40(36,37)28-3/h4-6,11-12,16-17,28H,7-10,13-14H2,1-3H3,(H,29,30,31)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.794	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00434 BindingDB Entry DOI: 10.7270/Q24Q7ZVJ
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