Found 4 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform' and Ligand = 'BDBM50387528' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50387528
(CHEMBL2059908)Show InChI InChI=1S/C12H11N5O2S/c1-20(18,19)10-4-9(5-14-6-10)8-2-3-11-15-12(13)16-17(11)7-8/h2-7H,1H3,(H2,13,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma by high throughput chemoproteomics binding assay |
Bioorg Med Chem Lett 22: 5257-63 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.049 BindingDB Entry DOI: 10.7270/Q2CR5VFP |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50387528
(CHEMBL2059908)Show InChI InChI=1S/C12H11N5O2S/c1-20(18,19)10-4-9(5-14-6-10)8-2-3-11-15-12(13)16-17(11)7-8/h2-7H,1H3,(H2,13,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121 BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50387528
(CHEMBL2059908)Show InChI InChI=1S/C12H11N5O2S/c1-20(18,19)10-4-9(5-14-6-10)8-2-3-11-15-12(13)16-17(11)7-8/h2-7H,1H3,(H2,13,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma assessed as inhibition of C5a-induced AKT phosphorylation at Ser473 by cell based assay |
Bioorg Med Chem Lett 22: 5257-63 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.049 BindingDB Entry DOI: 10.7270/Q2CR5VFP |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50387528
(CHEMBL2059908)Show InChI InChI=1S/C12H11N5O2S/c1-20(18,19)10-4-9(5-14-6-10)8-2-3-11-15-12(13)16-17(11)7-8/h2-7H,1H3,(H2,13,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma assessed as inhibition of fMLP-induced neutrophil migration assay by cell based assay |
Bioorg Med Chem Lett 22: 5257-63 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.049 BindingDB Entry DOI: 10.7270/Q2CR5VFP |
More data for this Ligand-Target Pair | |