Found 2 hits Enz. Inhib. hit(s) with Target = 'Placenta growth factor' and Ligand = 'BDBM50339192' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339192
(CHEMBL1689461)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r| Show InChI InChI=1S/C99H143N23O23S3/c1-53(2)41-72-99(144)121-38-20-27-75(121)94(139)113-70(44-62-47-103-52-105-62)89(134)115-73(92(137)110-67(26-17-19-37-101)87(132)117-81(54(3)4)95(140)108-65(85(102)130)35-40-146-10)50-147-148-51-74(93(138)109-66(25-16-18-36-100)86(131)111-69(43-60-46-104-64-24-15-14-23-63(60)64)90(135)119-83(56(7)8)97(142)120-84(57(9)123)98(143)114-72)116-96(141)82(55(5)6)118-91(136)71(45-80(128)129)112-88(133)68(42-59-21-12-11-13-22-59)107-77(125)49-145-48-76(124)106-61-31-28-58(29-32-61)30-33-78(126)122-39-34-79(122)127/h11-15,21-24,28-29,31-32,46-47,52-57,65-75,81-84,104,123H,16-20,25-27,30,33-45,48-51,100-101H2,1-10H3,(H2,102,130)(H,103,105)(H,106,124)(H,107,125)(H,108,140)(H,109,138)(H,110,137)(H,111,131)(H,112,133)(H,113,139)(H,114,143)(H,115,134)(H,116,141)(H,117,132)(H,118,136)(H,119,135)(H,120,142)(H,128,129)/t57-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,81+,82+,83+,84+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339192
(CHEMBL1689461)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r| Show InChI InChI=1S/C99H143N23O23S3/c1-53(2)41-72-99(144)121-38-20-27-75(121)94(139)113-70(44-62-47-103-52-105-62)89(134)115-73(92(137)110-67(26-17-19-37-101)87(132)117-81(54(3)4)95(140)108-65(85(102)130)35-40-146-10)50-147-148-51-74(93(138)109-66(25-16-18-36-100)86(131)111-69(43-60-46-104-64-24-15-14-23-63(60)64)90(135)119-83(56(7)8)97(142)120-84(57(9)123)98(143)114-72)116-96(141)82(55(5)6)118-91(136)71(45-80(128)129)112-88(133)68(42-59-21-12-11-13-22-59)107-77(125)49-145-48-76(124)106-61-31-28-58(29-32-61)30-33-78(126)122-39-34-79(122)127/h11-15,21-24,28-29,31-32,46-47,52-57,65-75,81-84,104,123H,16-20,25-27,30,33-45,48-51,100-101H2,1-10H3,(H2,102,130)(H,103,105)(H,106,124)(H,107,125)(H,108,140)(H,109,138)(H,110,137)(H,111,131)(H,112,133)(H,113,139)(H,114,143)(H,115,134)(H,116,141)(H,117,132)(H,118,136)(H,119,135)(H,120,142)(H,128,129)/t57-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,81+,82+,83+,84+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to human PlGF-1 |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this Ligand-Target Pair | |