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Found 1 hit Enz. Inhib. hit(s) with Target = 'Plasmepsin IV [1-448]' and Ligand = 'BDBM50461480'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Plasmepsin IV [1-448]


(Plasmodium falciparum)		BDBM50461480
PNG
(CHEMBL4225038)
Show SMILES Nc1nc2cc(cc(-c3ccc(cc3)C(O)=O)c2c(=O)n1CC1CCCO1)-c1ccccc1
Show InChI InChI=1S/C26H23N3O4/c27-26-28-22-14-19(16-5-2-1-3-6-16)13-21(17-8-10-18(11-9-17)25(31)32)23(22)24(30)29(26)15-20-7-4-12-33-20/h1-3,5-6,8-11,13-14,20H,4,7,12,15H2,(H2,27,28)(H,31,32)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Latvian Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin 4 using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by...

Bioorg Med Chem 26: 2488-2500 (2018)


Article DOI: 10.1016/j.bmc.2018.04.012
BindingDB Entry DOI: 10.7270/Q2X63QKH
More data for this
Ligand-Target Pair