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Found 1 hit Enz. Inhib. hit(s) with Target = 'Plasmepsin IV [1-448]' and Ligand = 'BDBM50513814'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Plasmepsin IV [1-448]


(Plasmodium falciparum)		BDBM50513814
PNG
(CHEMBL4585628)
Show SMILES CCCCCCCc1ccc(cc1)S(=O)(=O)C1C2CCC(N2)C1NCc1ccc2ccccc2c1 |TLB:23:22:21:19.18,THB:13:16:21:19.18|
Show InChI InChI=1S/C30H38N2O2S/c1-2-3-4-5-6-9-22-13-16-26(17-14-22)35(33,34)30-28-19-18-27(32-28)29(30)31-21-23-12-15-24-10-7-8-11-25(24)20-23/h7-8,10-17,20,27-32H,2-6,9,18-19,21H2,1H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 210n/an/an/an/an/an/a



Latvian Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin 4 using fluorescently labeled peptide substrate by fluorescence method

J Med Chem 62: 8931-8950 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00184
BindingDB Entry DOI: 10.7270/Q2P55RVR
More data for this
Ligand-Target Pair