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Found 1 hit Enz. Inhib. hit(s) with Target = 'Plasmepsin IV [1-448]' and Ligand = 'BDBM50513846'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Plasmepsin IV [1-448]


(Plasmodium falciparum)		BDBM50513846
PNG
(CHEMBL4456145)
Show SMILES CC(C)CCCCc1ccc(cc1)S(=O)(=O)C1C2CCC(N2)C1NCc1ccc2ccccc2c1 |TLB:23:22:21:19.18,THB:13:16:21:19.18|
Show InChI InChI=1S/C30H38N2O2S/c1-21(2)7-3-4-8-22-12-15-26(16-13-22)35(33,34)30-28-18-17-27(32-28)29(30)31-20-23-11-14-24-9-5-6-10-25(24)19-23/h5-6,9-16,19,21,27-32H,3-4,7-8,17-18,20H2,1-2H3
PDB

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PC sid
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Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Latvian Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Inhibition of Plasmodium falciparum plasmepsin 4 using fluorescently labeled peptide substrate by fluorescence method

J Med Chem 62: 8931-8950 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00184
BindingDB Entry DOI: 10.7270/Q2P55RVR
More data for this
Ligand-Target Pair