Found 2 hits Enz. Inhib. hit(s) with Target = 'Plasminogen' and Ligand = 'BDBM50532396' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Plasminogen
(Homo sapiens (Human)) | BDBM50532396
(CHEMBL4519782)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.[H][C@]1(Cc2ccc(NC(=O)CCN3CCN(CC3)CCC(=O)Nc3ccc(C[C@]([H])(NC1=O)C(=O)NCc1ccc(cc1)C(N)=N)cc3)cc2)NC(=O)Cc1ccccc1 |r,wU:49.47,wD:22.18,(53.09,-30.89,;53.88,-32.21,;53.13,-33.56,;55.43,-32.18,;56.83,-32.16,;56.47,-33.42,;56.43,-30.91,;53.5,-22.48,;54.29,-23.8,;53.54,-25.15,;55.84,-23.77,;57.25,-23.75,;56.88,-25,;56.84,-22.5,;53.81,-26.94,;54.61,-28.27,;53.86,-29.62,;56.16,-28.24,;57.56,-28.21,;57.2,-29.47,;57.15,-26.97,;36.73,-23.54,;36.69,-25.05,;36.64,-26.57,;35.66,-27.73,;34.16,-27.44,;33.17,-28.59,;33.68,-30.03,;32.93,-31.5,;33.67,-32.86,;32.86,-34.18,;35.21,-32.9,;35.95,-34.26,;37.49,-34.3,;38.29,-33,;39.81,-33.04,;40.52,-34.38,;39.73,-35.67,;38.21,-35.62,;42.06,-34.42,;42.88,-33.11,;44.42,-33.16,;45.15,-34.51,;45.18,-31.81,;43.39,-30.33,;43.76,-28.83,;42.65,-27.76,;41.16,-28.19,;40.61,-26.35,;40.66,-24.41,;40.7,-22.89,;39.32,-25.13,;38.03,-24.34,;38.07,-22.82,;41.94,-25.21,;41.9,-26.73,;43.28,-24.49,;44.57,-25.29,;45.91,-24.57,;47.2,-25.38,;48.54,-24.65,;48.58,-23.14,;47.28,-22.34,;45.95,-23.07,;49.92,-22.42,;51.22,-23.21,;49.96,-20.89,;40.78,-29.69,;41.9,-30.76,;35.18,-30.3,;36.16,-29.15,;35.39,-24.26,;34.04,-24.99,;33.99,-26.54,;32.72,-24.18,;32.76,-22.64,;34.12,-21.91,;34.16,-20.37,;32.85,-19.56,;31.48,-20.3,;31.45,-21.84,)| Show InChI InChI=1S/C44H51N9O5.3C2HF3O2/c45-42(46)34-12-6-33(7-13-34)29-47-43(57)37-26-31-8-14-35(15-9-31)48-39(54)18-20-52-22-24-53(25-23-52)21-19-40(55)49-36-16-10-32(11-17-36)27-38(44(58)51-37)50-41(56)28-30-4-2-1-3-5-30;3*3-2(4,5)1(6)7/h1-17,37-38H,18-29H2,(H3,45,46)(H,47,57)(H,48,54)(H,49,55)(H,50,56)(H,51,58);3*(H,6,7)/t37-,38+;;;/m0.../s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysis |
J Med Chem 59: 6370-86 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00606 BindingDB Entry DOI: 10.7270/Q2377D5T |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50532396
(CHEMBL4519782)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.[H][C@]1(Cc2ccc(NC(=O)CCN3CCN(CC3)CCC(=O)Nc3ccc(C[C@]([H])(NC1=O)C(=O)NCc1ccc(cc1)C(N)=N)cc3)cc2)NC(=O)Cc1ccccc1 |r,wU:49.47,wD:22.18,(53.09,-30.89,;53.88,-32.21,;53.13,-33.56,;55.43,-32.18,;56.83,-32.16,;56.47,-33.42,;56.43,-30.91,;53.5,-22.48,;54.29,-23.8,;53.54,-25.15,;55.84,-23.77,;57.25,-23.75,;56.88,-25,;56.84,-22.5,;53.81,-26.94,;54.61,-28.27,;53.86,-29.62,;56.16,-28.24,;57.56,-28.21,;57.2,-29.47,;57.15,-26.97,;36.73,-23.54,;36.69,-25.05,;36.64,-26.57,;35.66,-27.73,;34.16,-27.44,;33.17,-28.59,;33.68,-30.03,;32.93,-31.5,;33.67,-32.86,;32.86,-34.18,;35.21,-32.9,;35.95,-34.26,;37.49,-34.3,;38.29,-33,;39.81,-33.04,;40.52,-34.38,;39.73,-35.67,;38.21,-35.62,;42.06,-34.42,;42.88,-33.11,;44.42,-33.16,;45.15,-34.51,;45.18,-31.81,;43.39,-30.33,;43.76,-28.83,;42.65,-27.76,;41.16,-28.19,;40.61,-26.35,;40.66,-24.41,;40.7,-22.89,;39.32,-25.13,;38.03,-24.34,;38.07,-22.82,;41.94,-25.21,;41.9,-26.73,;43.28,-24.49,;44.57,-25.29,;45.91,-24.57,;47.2,-25.38,;48.54,-24.65,;48.58,-23.14,;47.28,-22.34,;45.95,-23.07,;49.92,-22.42,;51.22,-23.21,;49.96,-20.89,;40.78,-29.69,;41.9,-30.76,;35.18,-30.3,;36.16,-29.15,;35.39,-24.26,;34.04,-24.99,;33.99,-26.54,;32.72,-24.18,;32.76,-22.64,;34.12,-21.91,;34.16,-20.37,;32.85,-19.56,;31.48,-20.3,;31.45,-21.84,)| Show InChI InChI=1S/C44H51N9O5.3C2HF3O2/c45-42(46)34-12-6-33(7-13-34)29-47-43(57)37-26-31-8-14-35(15-9-31)48-39(54)18-20-52-22-24-53(25-23-52)21-19-40(55)49-36-16-10-32(11-17-36)27-38(44(58)51-37)50-41(56)28-30-4-2-1-3-5-30;3*3-2(4,5)1(6)7/h1-17,37-38H,18-29H2,(H3,45,46)(H,47,57)(H,48,54)(H,49,55)(H,50,56)(H,51,58);3*(H,6,7)/t37-,38+;;;/m0.../s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysis |
J Med Chem 59: 6370-86 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00606 BindingDB Entry DOI: 10.7270/Q2377D5T |
More data for this Ligand-Target Pair | |