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Found 1 hit Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase tankyrase-1' and Ligand = 'BDBM50505335'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM50505335
PNG
(CHEMBL4584689)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1nc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C20H21FN4O/c1-13-11-15(21)12-17-18(13)22-19(23-20(17)26)14-3-5-16(6-4-14)25-9-7-24(2)8-10-25/h3-6,11-12H,7-10H2,1-2H3,(H,22,23,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



Merck Healthcare KGaA

Curated by ChEMBL


Assay Description
Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...

J Med Chem 62: 7897-7909 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00656
BindingDB Entry DOI: 10.7270/Q2FJ2M28
More data for this
Ligand-Target Pair