Found 2 hits Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase tankyrase-2' and Ligand = 'BDBM50579980' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50579980
(CHEMBL5077466 | US11926614, Example 186)Show SMILES FC(F)Oc1ccc(nc1)-c1nnc([C@H]2C[C@@H](C2)NC(=O)c2cc(F)cc3nccnc23)n1-c1ccccc1F |r,wU:16.19,wD:14.14,(38.11,-15.34,;39.01,-14.11,;38.39,-12.72,;40.52,-14.27,;41.42,-13.03,;42.94,-13.19,;43.84,-11.96,;43.22,-10.57,;41.7,-10.41,;40.8,-11.64,;44.11,-9.35,;43.64,-7.87,;44.88,-6.96,;46.14,-7.87,;47.61,-7.39,;48.98,-8.1,;49.69,-6.72,;48.31,-6.01,;51.17,-6.25,;51.49,-4.73,;50.34,-3.7,;52.97,-4.25,;53.27,-2.73,;54.74,-2.25,;55.05,-.76,;55.9,-3.29,;55.58,-4.8,;56.72,-5.83,;56.41,-7.34,;54.93,-7.82,;53.79,-6.79,;54.11,-5.28,;45.66,-9.35,;46.56,-10.58,;45.93,-11.97,;46.83,-13.2,;48.35,-13.04,;48.96,-11.64,;48.06,-10.41,;48.68,-9.02,)| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50579980
(CHEMBL5077466 | US11926614, Example 186)Show SMILES FC(F)Oc1ccc(nc1)-c1nnc([C@H]2C[C@@H](C2)NC(=O)c2cc(F)cc3nccnc23)n1-c1ccccc1F |r,wU:16.19,wD:14.14,(38.11,-15.34,;39.01,-14.11,;38.39,-12.72,;40.52,-14.27,;41.42,-13.03,;42.94,-13.19,;43.84,-11.96,;43.22,-10.57,;41.7,-10.41,;40.8,-11.64,;44.11,-9.35,;43.64,-7.87,;44.88,-6.96,;46.14,-7.87,;47.61,-7.39,;48.98,-8.1,;49.69,-6.72,;48.31,-6.01,;51.17,-6.25,;51.49,-4.73,;50.34,-3.7,;52.97,-4.25,;53.27,-2.73,;54.74,-2.25,;55.05,-.76,;55.9,-3.29,;55.58,-4.8,;56.72,-5.83,;56.41,-7.34,;54.93,-7.82,;53.79,-6.79,;54.11,-5.28,;45.66,-9.35,;46.56,-10.58,;45.93,-11.97,;46.83,-13.2,;48.35,-13.04,;48.96,-11.64,;48.06,-10.41,;48.68,-9.02,)| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human TNKS2 (873 to 1162 residues) incubated for 20 hrs in presence of NAD |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01264
BindingDB Entry DOI: 10.7270/Q21R6VDH |
More data for this
Ligand-Target Pair | |
Search and Browse
