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Found 1 hit Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid 5-lipoxygenase' and Ligand = 'BDBM50085215'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))
BDBM50085215
PNG
(2-{Cyclohexyl-[4-(quinolin-2-ylmethoxy)-phenyl]-me...)
Show SMILES CC\C(=N/OC(C1CCCCC1)c1ccc(OCc2ccc3ccccc3n2)cc1)C(O)=O
Show InChI InChI=1S/C27H30N2O4/c1-2-24(27(30)31)29-33-26(20-9-4-3-5-10-20)21-13-16-23(17-14-21)32-18-22-15-12-19-8-6-7-11-25(19)28-22/h6-8,11-17,20,26H,2-5,9-10,18H2,1H3,(H,30,31)/b29-24+
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n/an/a 30n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay


J Med Chem 43: 690-705 (2000)


BindingDB Entry DOI: 10.7270/Q2HD7WCR
More data for this
Ligand-Target Pair