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Found 1 hit Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid 5-lipoxygenase' and Ligand = 'BDBM50512025'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50512025
PNG
(CHEMBL4451916)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)C(=O)OCCCN1CCOCC1
Show InChI InChI=1S/C24H25F3N4O5S/c25-24(26,27)18-4-2-17(3-5-18)22-16-21(23(32)36-13-1-10-30-11-14-35-15-12-30)29-31(22)19-6-8-20(9-7-19)37(28,33)34/h2-9,16H,1,10-15H2,(H2,28,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 750n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat 5-LOX assessed as calcium ionophore A23187-stimulated LTB4 production preincubated for 30 mins followed by calcium i...

Eur J Med Chem 169: 168-184 (2019)


Article DOI: 10.1016/j.ejmech.2019.03.008
BindingDB Entry DOI: 10.7270/Q2K077MH
More data for this
Ligand-Target Pair