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Found 1 hit Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid 5-lipoxygenase' and Ligand = 'BDBM50521290'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50521290
PNG
(CHEMBL4521577)
Show SMILES Clc1ccccc1NC(=O)Nc1ccc(OCc2nc3ccccc3s2)cc1
Show InChI InChI=1S/C21H16ClN3O2S/c22-16-5-1-2-6-17(16)25-21(26)23-14-9-11-15(12-10-14)27-13-20-24-18-7-3-4-8-19(18)28-20/h1-12H,13H2,(H2,23,25,26)
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PC cid
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Article
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n/an/a 360n/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in human neutrophils preincubated for 10 mins followed by Ca2+ ionophore A23187 addition and measured after 10 mins by RP-HPLC ana...

ACS Med Chem Lett 10: 62-66 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00415
BindingDB Entry DOI: 10.7270/Q2J106JK
More data for this
Ligand-Target Pair