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Found 1 hit Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid 5-lipoxygenase' and Ligand = 'BDBM50521300'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50521300
PNG
(CHEMBL4456287)
Show SMILES Clc1cc(Cl)cc(NC(=O)Nc2ccc(OCc3nc4ccccc4s3)cc2)c1
Show InChI InChI=1S/C21H15Cl2N3O2S/c22-13-9-14(23)11-16(10-13)25-21(27)24-15-5-7-17(8-6-15)28-12-20-26-18-3-1-2-4-19(18)29-20/h1-11H,12H2,(H2,24,25,27)
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PC cid
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Article
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n/an/a 90n/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in human neutrophils preincubated for 10 mins followed by Ca2+ ionophore A23187 addition and measured after 10 mins by RP-HPLC ana...

ACS Med Chem Lett 10: 62-66 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00415
BindingDB Entry DOI: 10.7270/Q2J106JK
More data for this
Ligand-Target Pair