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Found 1 hit Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid 5-lipoxygenase' and Ligand = 'BDBM50521305'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50521305
PNG
(CHEMBL4468253)
Show SMILES Cc1cc(NC(=O)Nc2ccccc2Cl)ccc1OCc1nc2ccccc2s1
Show InChI InChI=1S/C22H18ClN3O2S/c1-14-12-15(24-22(27)26-17-7-3-2-6-16(17)23)10-11-19(14)28-13-21-25-18-8-4-5-9-20(18)29-21/h2-12H,13H2,1H3,(H2,24,26,27)
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PC cid
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Article
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n/an/a 680n/an/an/an/an/an/a



University of Innsbruck

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in human neutrophils preincubated for 10 mins followed by Ca2+ ionophore A23187 addition and measured after 10 mins by RP-HPLC ana...

ACS Med Chem Lett 10: 62-66 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00415
BindingDB Entry DOI: 10.7270/Q2J106JK
More data for this
Ligand-Target Pair